Genomics Lab taking multiomics approach towards elucidating contributors to Cancer. PI: Dr. Yun Rose Li
Mutation Enrichment Analysis of Colorectal Cancer
Worked under Doctoral Candidate Isabel Chosco to determine impact of various lifestyle factors on mutation enrichment in Colorectal Cancer. Integrated WGS data from The Cancer Genome Atlas and various clinical variables to determine differential mutation enrichment.
Smoking Drivers Analysis
Worked under Doctoral Candidate Isabel Chosco to determine SBS mutation signature in various forms of cancer, leveraged STAR
Financial Economics Institute '24
Institute at Claremont McKenna College focusing on Computational Approaches to Financial Economics. PI: Dr. Benjamin Gillen.
On Subset Optimization
Aiming to understand the efficacy of subset optimization, a novel approach to mean-variance portfolio optimization, as an asset allocation strategy.
Lubbe Lab @ Feinberg SoM '22-'24
Human Genomics Lab at Northwestern Medicine studying genetic causes of motion-debilitating disease. PI: Dr. Steven Lubbe
Study focused on finding rare-variant contributors to Parkinsons' Disease as their low frequency makes them prone to marginalization in summary statistics.
Scoring of individuals in dataset using meta-5 summary statistics. Scoring was done via PRSice. IDs of affected individuals with low PRS scores were stored
Quantile plot generated from PRS Scoring
CADD annotations done via annovar. Coding variants with high CADD scores (i.e., > 12.37) were moved into another file, along with variants annotated as nonsense SNPs, splice site errors, and indels.
Quality-control on ampPD genetic data using PLINK. Filtered out variants with MAF > .05. Reintroduced variants from step 2 into dataset
Rare Variant Analysis done via SkatO
On Genetic Contributers to Early-Onset Alzheimers Disease
Genome-Wide Association aiming to better understand genetic contributors to Early-Onset Alzhemiers Disease. This project focused mostly on rare varaints (i.e., variants with a minor allele frequency less than .05
On Genetic Causes of Parkinsons'
Training study. Genome-wide association study to uncover genetic causes of Parkinsons' disease focusing mostly on common variant contributors.
Drug Discovery '21-'22
Discovery Lab at IMSA focusing on compound growth using ligand-based drug design. PI: Dr. John Thurmond
COVID Moonshot
PostEra crowd sourced project for the discovery of SARS-CoV-2 (CoVid) therapeutics
